System for performing chemical, biological and/or medical processes

专利摘要:
The present invention provides a system for performing chemical, biological and/or medical processes comprising holding means for holding a plurality of containers, whereby the holding means is configured such that the containers are arranged in at least two essentially parallel rows along a first direction when held by the holding means. The system further comprises a gas outlet arranged to provide a gas flow along the first direction and along openings of containers of at least one of the at least two rows of containers and at least one flow barrier is arranged along the first direction and in between the at least two rows of containers for separating openings of one of the at least two rows of containers from openings of the other one of the at least two rows of containers.
公开号:ES2715518A2
申请号:ES201990036
申请日:2017-11-13
公开日:2019-06-04
发明作者:Fernandez Aitor Ezkerra；Eneriz Diana Eneriz；Pastor Yaiza Belacortu；Ruiz Javier Berganzo；Lazcano Iñigo Aranburu；Poza Miguel Angel Roncales
申请人:Brio Apps Alphasip S L；
IPC主号:

专利说明:

[0001] SYSTEM FOR CARRYING OUT CHEMICAL, BIOLOGICAL AND / OR PROCEDURES
[0002] 1. Field of the invention
[0003]
[0004] The present invention relates to a system for carrying out chemical, biological and / or medical procedures, preferably following respective protocols.
[0005]
[0006] 2. Technical background
[0007]
[0008] In particular, for compact systems at the laboratory level for carrying out chemical, biological and / or medical procedures, such as analytical procedures or the like, it is often crucial to prevent contamination of substances contained in a container, such as for example a test tube, by aerosols or vaporized substances that come from test tubes located in the vicinity. In view of this, the objects of the present invention are directed to provide a system that prevents such container contamination by aerosols, vaporized substances or the like. The objects of the invention, in particular, are aimed at providing a compact, completely enclosed system that can be applied as laboratory equipment.
[0009]
[0010] The chemical, biological and / or medical procedures that follow the corresponding protocols are carried out using containers or containers such as test tubes, vials, plates, flasks, channels, surfaces or the like, whereby substances such as reagents or products of The reaction is introduced and extracted from them, for example, using suitable pipettes. Currently, for example, the analysis procedures of genetic materials or proteins have gained interest.
[0011]
[0012] In conventional systems such as the system disclosed in WO 2010/089138 A1, a plurality of containers are retained in corresponding retention elements by forming rows so that substances can be added or removed from the containers at the same time or one after the other.
[0013]
[0014] During such procedures, it is common for the containers to remain open in such a way that the reagents within the containers can be handled. However, it is important that the containers are separated from each other since the content can be highly sensitive, dangerous, polluting or volatile. In certain cases, a corresponding protocol for the procedure in question may require different transfers of reagents between containers, which can promote the generation of aerosols. Such aerosols can move undesirably to adjacent containers or containers and can thus cause contamination thereof.
[0015]
[0016] The objects of the present invention are directed to providing a system that reduces or even completely prevents such contamination. Therefore, it is an object of the present invention to provide a system for carrying out chemical, biological and / or medical procedures that can reduce such contamination in an effective and efficient manner, so that the corresponding system components must be easy to control. and not complex. The system should preferably be a compact system, completely closed at the laboratory level.
[0017]
[0018] This object is achieved by the content of the independent claims.
[0019]
[0020] 3. Summary of the invention
[0021]
[0022] According to the invention, a system is provided for carrying out chemical, biological and / or medical procedures. Such procedures may include analyzes of specific substances or other reactions that may follow protocols such as chemical, biological and / or medical protocols. As will be clear to the person skilled in the art, a chemical, biological and / or medical protocol is a sequence of steps carried out, for example, during an analysis procedure or a reaction procedure.
[0023]
[0024] According to the invention, the system comprises a retaining means for retaining a plurality of containers. The retaining means may comprise, for example, orifices or different means for housing the containers or they may be formed integrally with the containers. Thus, the containers are suitable for containing substances relevant to the process in question such as reactants or reaction products. The procedures can therefore be carried out in those containers or containers. In this way reactants and / or reaction products can be introduced or removed from said containers using, for example, pipettes during the procedure as required, for example, by the respective protocol. As will be clear to the skilled artisan, the usual reagents of interest may be, by way of example, samples, buffers, solutions or the like. Suitable containers may be test tubes, vials, plates, flasks, channels, surfaces or the like.
[0025]
[0026] Additionally according to the invention, the retaining means is configured and / or disposed of such that the containers are arranged in at least two substantially parallel rows along a first direction when they are retained by the retaining means. As will be understood by the person skilled in the art, due, for example, to manufacturing tolerances, perfect parallelism may not be achieved in such a way that the essentially parallel term is to be understood as being parallel to the usual construction tolerances.
[0027]
[0028] The retaining means may comprise a suitable frame structure or the like for retaining the containers or into which containers can be inserted. The containers can be formed, in a similar way, in an integrated manner with such a frame structure. With such a frame structure, the containers are arranged in at least two (or more) rows along a first direction. Depending on the apparatus, said direction may be a direction of movement of the containers towards a position for interaction with a pipette. Alternatively, a plurality of pipettes corresponding to a plurality of containers may be provided within a row or all rows to allow simultaneous treatment of the containers. In addition, the retaining means may be a frame structure adapted to retain a plurality of containers such that the containers form a network (ie, the containers being arranged in essentially parallel rows and essentially parallel columns).
[0029]
[0030] The system further comprises a gas outlet arranged to provide a gas flow along the first direction. Preferably, the gas is air. Alternatively, suitable gases include nitrogen, argon and helium. A suitable gas outlet can be a single orifice, multiple orifices, ie at least two orifices, an array of orifices and a suitable nozzle. The outlet may have an essentially circular shape or an elongated shape as desired. In a preferred embodiment, the gas outlet comprises an array of holes. Such a matrix is advantageous since it can be adapted to the needs of the system and in particular can be used to extend the gas flow to a desired height as described below. In a preferred embodiment, the gas outlet comprises a matrix of circular holes, preferably with diameters between 1 mm and 3 mm, spaced between 1.5 mm and 3.5 mm measured from center to center. Preferably, the gas outlet is adapted to provide a gas flow, in an area of between 1 cm and 10 cm in length by a length of between 1 cm and 15 cm. The gas outlet is preferably provided at a distance of between 1 cm and 5 cm before the openings of the containers. The gas outlet is arranged to provide gas flow along the openings of the containers of at least one of the at least two rows of containers. Although it may be possible to provide a gas flow selectively to a single row if desired, in a preferred embodiment, the gas outlet is arranged to provide the gas flow along the openings of the containers of a plurality of rows of containers. This can be achieved by providing the gas outlet comprising an array of holes.
[0031] According to the invention, at least one flow barrier is arranged along the first direction and between the at least two rows of containers to separate the openings of one of the at least two rows of containers from the openings of the other of the at least two rows of containers. In other words, the flow barrier is adapted to prevent a flow or transfer of gas, aerosols, vaporized reagent or the like from one of the at least two rows of containers to the openings of the other of the at least two rows of containers.
[0032]
[0033] In a preferred embodiment, the retaining means is configured in such a way that at least within each row, the openings of the containers are disposed within a common plane along the first direction when they are retained by the retaining means, whereby the gas outlet is arranged to provide the gas flow along at least all the openings within a row. Therefore, part of the containers or all the containers can be retained by the retention element in such a way that the openings of the containers are essentially maintained in a common plane. Flow barriers are arranged between pairs of rows of containers extending in parallel along the first direction and in a height direction perpendicular to the first direction and perpendicular to said common plane of the openings. Due to the arrangement of the at least one flow barrier between the at least two rows of containers, the at least two rows of containers are separated from each other. Therefore, unwanted transfer, for example of aerosols or vaporized substances, is effectively prevented. Additionally, because gas flow, aerosols or the like generated within each row is provided, it can be effectively transported away from the respective reaction zones.
[0034]
[0035] The present invention further provides a method for carrying out chemical, biological and / or medical procedures comprising retaining a plurality of containers in at least two essentially parallel rows along a first direction.
[0036]
[0037] According to the invention, the method further comprises providing a gas flow along the first direction and at least along the openings of the containers of one of the at least two rows of containers. The method further comprises separating the openings of one of the at least two rows of containers from the openings of the other of the at least two rows of containers using at least one flow barrier disposed along the first direction and between the two. minus two rows of containers.
[0038] As will be understood by the person skilled in the art, said method according to the invention can be combined with the preferred embodiments described in relation to the system according to the invention.
[0039]
[0040] 4. Description of the preferred embodiments
[0041]
[0042] In the following, the invention is described by way of example with reference to the accompanying figures in which:
[0043]
[0044] Figure 1 shows a three-dimensional view of a system for carrying out chemical, biological and / or medical procedures;
[0045]
[0046] Figure 2 shows a retaining means for retaining a plurality of containers;
[0047]
[0048] Figure 3 is a three-dimensional illustration of the retention means which retains a plurality of containers, flow barriers and a gas flow along the openings of the containers of a row of containers; Y
[0049]
[0050] Figure 4 shows an additional retaining means for retaining a plurality of containers.
[0051]
[0052] Figure 1 shows an example of a system 100 carrying out chemical, biological and / or medical procedures. The system 100 comprises a main housing 101 that covers internal components such as a controller (microprocessor) that is configured to control operations of the components of the system. As will be clear to the skilled person, operations of system components in the controller can be implemented using suitable software.
[0053]
[0054] The housing 101 of the system 101 encloses a partially open process space 103 within which the procedures discussed above are carried out. In the figure, a pipette 105 is visible through an opening in a side wall of the housing 101. The pipette is mounted on an arm 106 which is controlled by a controller (microprocessor) of the system. A door 107 is provided in a front wall of the housing 101 that an operator can open to introduce containers into the system for further procedures. To this end, within the space 103, a retaining means 200 (eg, suitable frame structures, not visible in the figure) can be removably disposed to house the containers. Can providing an appropriate algorithm to the controller such that using the arm 106, chemical, biological and / or medical procedures can be carried out automatically following a suitable protocol, for example implemented as software by the controller. Thus, in a preferred embodiment, the system comprises means 106, 105, preferably at least one pipette 105, for adding or removing a substance to or from at least one of the plurality of containers. Preferably, the system further comprises a controller configured to automatically control said means, preferably said pipette.
[0055]
[0056] Figure 2 shows a frame 201 as an exemplary part of the retaining means 200. Introduced in the system 100, such a frame extends along the first direction 601 (see also Figure 3 below) and includes a plurality of cavities 203 or holes 203 with an essentially circular shape, to accommodate each cavity 203 a container 300 Alternatively, the containers 300 can be formed integrally with the frame 201. The containers 300 shown in Figure 2 (the frame 201 retains by way of example eight containers 300 of which only one is indicated by a reference number) are therefore a plurality of containers that are arranged in a row along a first direction retaining a part of the retaining means.
[0057]
[0058] For example, using a frame 201 of this type, in a preferred embodiment, the retaining means 200 comprises at least two frames 201 that extend along the first direction 601, the frames 201 being removably inserted into the housing 101 of the system 100, each frame 201 having a plurality of cavities 203 with essentially circular shape, each cavity 203 being for retaining a respective container 300 of the plurality of containers 300.
[0059]
[0060] As shown in Figure 2, when introduced into the frame 201, the openings 301 of the containers 300 are disposed within a common plane along the first direction 601, whereby in the example shown said common plane it is essentially a plane that also includes the cavities 203 of the frame 201. In this way, preferably, an opening 301 of a respective container 300 of the plurality of containers 300 is disposed essentially at a same height 603 (see Figure 3 below) that the cavity 301 is essentially circular in shape when the respective container 300 is retained by the corresponding frame.
[0061]
[0062] The frame can be provided with a two-dimensional code, for example a QR code, to a suitable position such as for example on a top surface at the end left of the frame 201 in FIG. 2. Therefore, in a preferred embodiment, the frame 201 is provided with a two-dimensional code, preferably a QR code (Quick Response, quick response), to identify substances per container or procedures carried to Accordingly, the system 100 preferably comprises means for reading said two-dimensional code, when the frame 201 is inserted into the system and the controller is configured to automatically carry out a procedure according to the information. stored in the two-dimensional code. As illustrated further in FIG. 2, the frame may retain one or more different containers or containers 313 that may be used to retain additional substances as desired.
[0063]
[0064] Figure 3 schematically illustrates the retaining means 200 retaining a plurality of containers 300. As shown, the retaining means 200 is configured in such a way that the plurality of containers 300 are arranged in at least two rows essentially parallel to the along the first direction 601 when they are retained by the retaining means 200. In the example shown, the first two rows parallel to address 601 visible in the figure are indicated by reference numerals 350 and 360. Retention means 200 can be made, for example, by multiple frames 201 (three in the example shown in FIG. 3) as shown in FIG. 2. However, the holding means 200 can also be realized as a holding element for retaining a network of containers 300 so that rows of containers are formed along the first direction 601 as illustrated.
[0065]
[0066] As can be deduced from Figure 3, the system further comprises a gas outlet (not shown) arranged to provide a gas flow (illustrated by arrows forming groups 501, 503) along the first direction 601 and at least along the openings of the containers of one of the at least two rows of containers. In the example shown, the gas flow occurs along the openings of the containers in row 350. The gas flow may be limited to a single row such as said row 350, but may also be along more than one or all of the rows. As shown, two flow barriers 400, in the example shown wall-like elements 400, are arranged along the first direction 601 and between at least two rows of containers 300 to separate the openings 301 from one of the at least two rows of containers of the openings 301 of the other of the at least two rows of containers. In Figure 3, a first flow barrier 400 is provided between row 350 and row 360 to prevent a transfer of gas, gaseous substances, aerosols and the like between openings 301 of containers 300 for example of row 350 at openings 301 of the containers 300 of the row 360, and vice versa.
[0067]
[0068] As further illustrated in Figure 3, in a preferred embodiment, the at least one flow barrier 400 extends along the first direction 601 from a first position 801 before the vessels along the first direction 601 to a second position 803 behind the containers 300 along the first direction 601 so that it is placed between all the containers 300 of the at least two rows 350, 360 of containers 300. As shown, each flow barrier it extends along the first direction and along a second direction 603, that is to say a height direction. In other words, preferably, the at least one flow barrier is essentially wall-shaped and the height of the at least one flow barrier is measured in a direction essentially perpendicular to said common plane. As illustrated, in a preferred embodiment, the at least one flow barrier 400 has an essentially uniform height along its length that is between 0.5 cm and 10 cm, preferably between 0.8 cm and 9 cm , more preferably between 0.9 cm and 8 cm and most preferably between 1 cm and 7 cm.
[0069]
[0070] According to the height, in a preferred embodiment, the length of the at least one flow barrier in the first direction is between 0.5 cm and 50 cm, preferably between 0.8 cm and 40 cm, more preferably between 1 cm and 30 cm, and most preferably between 1 cm and 20 cm.
[0071]
[0072] In Figure 3, two exemplary flow barriers 400 are provided for separating containers or rows of containers. The horizontal flow runs from a gas outlet (not shown) which is disposed at a distance in front of the barriers. It follows that the distance between the gas outlet and the flow barriers should not be too small, so that a fully developed non-turbulent and uniform gas flow is applied. In a preferred embodiment, the distance between the at least one flow barrier and the gas outlet is not less than 1 cm, preferably not less than 2 cm, more preferably not less than 3 cm, even more preferably not less than 4 cm , and most preferably not less than 5 cm. It follows that maintaining such a distance helps a desirable flow development helping to prevent turbulence. Turbulence is not desirable since it can promote the exchange of aerosols, for example, over flow barriers.
[0073]
[0074] In a preferred embodiment, the system comprises at least three, preferably a plurality of rows of containers and at least two, preferably a plurality of flow barriers disposed respectively between pairs of rows of containers, whereby the gas outlet is disposed of so that the gas flow comprises a first part that flows to along at least all the openings of the containers within each row between the flow barriers and a second part flowing above the flow barriers. As can be deduced from Figure 3, part of the gas flow (a first part) is channeled through said barriers, ie it flows between the two barriers, and a part (a second part) flows over or over the barriers at a higher speed. The difference in speed is due to the fluid resistance produced by the aspect ratio (height / separation) of the space between the barriers. As illustrated in the figure, at a certain length behind the channels, the gas or air flow is withdrawn downward or, alternatively, upwards, laterally, diagonally or in the direction of flow.
[0075]
[0076] To this end, in a preferred embodiment, the system 100 comprises at least two flow barriers 400 and a negative pressure source 700, preferably a pump 700, to create a pressure difference between the negative pressure source 700 and the negative pressure source 700. gas in such a way that the gas provided by the gas outlet moves towards the source 700 of negative pressure. By providing the negative pressure source 700 it becomes possible to generate a directed gas flow (preferably air flow) from the gas outlet to the negative pressure source. This configuration turned out to be advantageous since by directing the gas flow in this manner, turbulences that could otherwise promote unwanted exchange for example of aerosols between rows with a simple non-complex construction can be effectively prevented.
[0077]
[0078] Preferably, the gas outlet is arranged to cause the gas flow to flow along an initial flow direction (for example along the first direction 601), so that after having passed at least the openings of all the containers of a row 350, the gas flow is directed in a predetermined direction different from the initial direction, for example downwards as shown in figure 3.
[0079]
[0080] In a preferred embodiment, the system 100 further comprises a controller for controlling the negative pressure source 700 such that the gas flow velocity between the at least two flow barriers is between 100 and 200 cm3 / s, preferably between 120 and 180 cm3 / s, more preferably between 140 and 170 cm3 / s, and most preferably between 160 and 170 cm3 / s. These values for the gas flow rate are given per row of containers 300. Therefore, the system can be extended, that is, it can comprise a greater number of rows of containers, so that these values are essentially constant per row, of essentially independent of the number of rows, that is, the size of the system. Preferably, in this embodiment, the values of the flow rate are such that the gas velocity between the gas outlet and the at least one Flow barrier is between 0.3 m / s and 0.5 m / s. It follows that above this value, the flow was no longer laminar but began to be turbulent. In addition, the high speeds over the openings 301 of the tubes 300 can cause the pressure to decrease locally, thus promoting evaporation. This can occur in high pressure systems such as air jets.
[0081]
[0082] In a preferred embodiment, the source of negative pressure is a pump configured to pump gas at a flow rate that is not less than that of the gas outlet per row of containers.
[0083] Thus, in a preferred embodiment, a gas flow preferably of low pressure is conducted locally along a series of flow barriers, placed parallel to the direction of gas flow, ie along the first direction. The air flow is preferably extracted by a source of negative pressure, which causes the flow to be directed (upwards, downwards, laterally, diagonally or along its initial). Unlike, for example, conventional air-only systems, this solution ensures that turbulence will not cause the accidental transport of aerosols or other elements (such as small particles) into containers in adjacent rows. Alternative solutions, such as high-pressure jets, are more expensive and complex (for example, a fine flow concentration is required), so that a large amount of turbulence can cause the uncontrolled propagation of aerosols, particularly at the boundary between the jets or if any type of barrier or obstacle. Similarly, high speeds above the containers can cause a decrease in local pressure and promote evaporation. Furthermore, with such solutions extraction is only possible in the direction of gas flow, with a high risk of jet contact, which can cause uncontrolled air currents within the device and potential contamination deposits.
[0084]
[0085] Unlike conventional solutions, according to the invention, the use of parallel flow barriers ensures desirable flow development and more predictable air conditions. In addition, the barriers prevent the lateral transfer of aerosols. In a preferred embodiment, the relationship between the width and the height of the barriers can be chosen such that the air flow is stronger above the barriers than along the barriers. In this way, two simultaneous phenomena can develop. On the one hand, the above mentioned unidirectional transport of aerosols in parallel to the barriers is possible. On the other hand, a higher gas velocity or air cap is developed above the barriers, which further avoids the transfer of aerosol through the barriers. It follows that this solution is ideal for the handling of containers with liquid handling devices, robots, pipettes or fluid handling tools that can be inserted and removed from the tubes.
[0086]
[0087] Furthermore, since the gas flow velocity can also be kept low, it is possible to extract this gas or air in a short length after the barriers with low turbulence and in any direction, by means of a source of negative pressure. This source redirects the flow to itself, prevents mechanisms of aerosol propagation, such as by contact, and minimizes circulation to avoid accumulating contamination deposits.
[0088]
[0089] In a preferred embodiment, the negative source and the gas outlet can be part of the same gas / air circulation system, which helps to balance the positive and negative pressures required to direct the gas flow and to extract it. In another preferred embodiment, a filter (eg, HEPA or other) is provided in the circulation system that continuously removes the aerosols and helps to improve the quality of the gas within the device.
[0090]
[0091] Figure 4 shows a retaining means 200 comprising a further embodiment of a frame 201 '. Introduced in the system 100, such a frame extends along the first direction 601 (see also figure 3 below) and is adapted to retain at least two rows, in the example shown three rows 350, 360, 370 of containers 300
[0092]
[0093] The flow barriers 400 are arranged between rows 350, 360, 370 of containers. The flow barriers are arranged to channel or guide a gas flow (not shown) at least along the orifices 203 to remove gaseous substances, aerosols or the like. The flow barriers may be separate elements attached to the frame 201 'or may be an integrated part of a structure that also includes the frame 201'. Similarly, the containers may be removably inserted into corresponding holes in the frame 201 'but may also be formed integrally with the frame 201'.
[0094]
[0095] Figure 4 further shows containers 313, an additional container 313 being arranged per row 350, 360, 370 of containers. Such additional containers 313 may be used to contain a reagent different from that of the containers 300. As shown, additional flow barriers 401 are provided between the additional containers 313 that serve the same purpose as the flow barriers 400 that are disposed between the containers. rows 350, 360, 370 of containers 300.
[0096]
[0097] Examples
[0098]
[0099] In a particularly preferred embodiment, the system can be characterized by:
[0100] - The gas outlet is located 3 cm in front of the flow barriers 400, with an outlet air velocity of 0.5 m / s and a flow velocity of 165 cm3 / s per space between barriers.
[0101]
[0102] The height of the barriers 400 is 3 cm above the plane formed by the openings 301 of the containers 300 and the spacing between the barriers 400 is 1 cm. The containers 300 are located in rows in the gap between the barriers 400. The length of the barriers 400 is 12 cm.
[0103]
[0104] - The source of negative pressure has a cross section of 6 cm x 12 cm, starting 1 cm after the length of the barriers 803. The speed of the exit air is 0.5 m / s and the flow velocity is 165 cm3 / s by space between barriers 400.

权利要求:
Claims (14)
[1]
1. System (100) for performing chemical, biological and / or medical procedures comprising
a retaining means (200) for retaining a plurality of containers (300), whereby the retaining means (200) is configured in such a way that the containers (300) are arranged in at least two rows (350, 360, 370) essentially parallel along a first direction (601) when they are retained by the retaining means (200),
characterized because
the system (100) further comprises a gas outlet arranged to provide a gas flow (501, 503) along the first direction (601) and along the openings of the containers (300) of at least one of the at least two rows (350, 360) of containers (300),
at least one flow barrier (400) arranged along the first direction (601) and between the at least two rows (350, 360) of containers (300) in a direction of height perpendicular to the first direction and perpendicular to said common plane of the openings, to prevent a transfer of gas, gaseous substances, aerosols and the like between the openings 301 of the containers of the row 350 to the openings 301 of the containers 300 of the row 360, and vice versa,
and characterized in that the gas outlet is arranged in such a way that the gas flow comprises a first part that flows along at least all of the openings of the containers (300) within each row between the flow barriers (400) and a second part that flows above the flow barriers (400).
[2]
System (100) according to claim 1, characterized in that the retaining means (200) is configured in such a way that at least within each row, the openings of the containers (300) are disposed within a common plane as length of the first direction (601) when they are retained by the retaining means (200), whereby the gas outlet is arranged to provide the gas flow (501, 503) along at least all the openings within of a row.
[3]
System (100) according to claim 1 or 2, characterized in that the at least one flow barrier (400) extends along the first direction (601) from a first position (801) before the containers (300) ) along the first direction (601) to a second position (803) behind the containers (300) along the first direction (601) so that it is placed between all the containers (300) of the minus two rows (350, 360) of containers (300).
[4]
System (100) according to any one of the preceding claims, characterized in that the at least one flow barrier (400) has an essentially uniform height along its length, which is between 0.5 cm and 10 cm, preferably between 0.8 cm and 9 cm, more preferably between 0.9 cm and 8 cm and most preferably between 1 cm and 7 cm.
[5]
System (100) according to claim 4, characterized in that the retaining means (200) is configured in such a way that at least within each row, the openings of the containers (300) are disposed within a common plane as length of the first direction (601) when they are retained by the retaining means (200); whereby the at least one flow barrier (400) is essentially wall-like and so that the height of the at least one flow barrier (400) is measured in a direction essentially perpendicular to said common plane.
[6]
System (100) according to any one of the preceding claims, characterized in that the length of the at least one flow barrier (400) in the first direction (601) is between 0.5 cm and 50 cm, preferably between 0 , 8 cm and 40 cm, more preferably between 1 cm and 30 cm, and most preferably between 1 cm and 20 cm.
[7]
System (100) according to any one of the preceding claims, characterized in that the distance between the at least one flow barrier (400) and the gas outlet is not less than 1 cm, preferably not less than 2 cm, more preferably not less than 3 cm, even more preferably not less than 4 cm, and most preferably not less than 5 cm.
[8]
System (100) according to any one of the preceding claims, characterized in that the system (100) comprises at least two flow barriers (400) and a source (700) of negative pressure to create a pressure difference between the source ( 700) of negative pressure and the gas outlet in such a way that the gas provided by the gas outlet moves towards the source (700) of negative pressure, the system (100) further comprising a controller for controlling the source (700) of negative pressure such that the gas flow velocity between the at least two barriers (400) of flow is between 100 and 200 cm3 / s, preferably between 120 and 180 cm3 / s, more preferably between 140 and 170 cm3 / s, and most preferably between 160 and 170 cm3 / s.
[9]
System (100) according to any one of the preceding claims, characterized in that the system (100) comprises a source (700) of negative pressure to create a pressure difference between the source (700) of negative pressure and the gas outlet in such a way that the gas provided by the gas outlet moves towards the source (700) of negative pressure, the system (100) further comprising a controller for controlling the source (700) of negative pressure so that the speed of gas between the gas outlet and the at least one flow barrier (400) is between 0.1 m / s and 0.5 m / s, preferably between 0.2 m / s and 0.5 m / s, and more preferably between 0.3 m / s and 0.5 m / s.
[10]
System (100) according to any one of the preceding claims, characterized in that the gas outlet is arranged to cause the flow (501, 503) of gas to flow along an initial flow direction, whereby the system (100) further comprises a source (700) of negative pressure disposed in such a way that after having passed at least the openings of all the containers (300) of a row, the gas flow (501, 503) is directed in one direction different default from the initial address.
[11]
System (100) according to any one of the preceding claims, characterized in that the gas outlet comprises an array of holes.
[12]
System (100) according to any one of the preceding claims, characterized in that the retaining means (200) comprises a frame (201 ') extending along the first direction (601), and the frame can be inserted (201). ') removably in a main housing (101) of the system (100), the frame being adapted to retain at least two rows of containers (300).
[13]
System (100) according to any one of the preceding claims, characterized in that the source (700) of negative pressure is a pump configured to pump gas at a flow rate that per row of containers 300 is not less than that of the gas outlet.
[14]
14. Method for carrying out chemical, biological and / or medical procedures comprising
retaining a plurality of containers (300) in at least two rows (350, 360) essentially parallel along a first direction (601),
characterized because
the method further comprises providing a gas flow (501, 503) along the first direction (601) and at least along the openings of the containers (300) of one of the at least two rows (350, 360) of containers (300),
separating the openings of one of the at least two rows (350, 360) of containers (300) from the openings of the other of the at least two rows (350, 360) of containers (300) using at least one barrier (400 ) of flow arranged along the first direction (601) and between the at least two rows (350, 360) of containers (300).

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同族专利:

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公开号 | 公开日

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ES2715518R1|2019-12-18|

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DE112017005675T5|2019-09-05|

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ES2715518B2|2020-07-14|

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WO2018087372A1|2018-05-17|

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优先权:

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申请号 | 申请日 | 专利标题

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EP16382525|2016-11-11|

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PCT/EP2017/079086|WO2018087372A1|2016-11-11|2017-11-13|System for performing chemical, biological and/or medical processes|

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